Overview

Angelica is a plant. The root, seed, leaf, and fruit are used to make medicine.

Angelica is used for heartburn (dyspepsia), intestinal gas (flatulence), loss of appetite (anorexia), overnight urination (nocturia), arthritis, stroke, dementia, circulation problems, "runny nose" (respiratory catarrh), nervousness and anxiety, fever, plague, and trouble sleeping (insomnia).

Some women use angelica to start their menstrual periods. Sometimes this is done to cause an abortion.

Angelica is also used to increase urine production, improve sex drive, stimulate the production and secretion of phlegm, and kill germs.

Some people apply angelica directly to the skin for nerve pain (neuralgia), joint pain (rheumatism), and skin disorders.In combination with other herbs, angelica is also applied to the skin for treating premature ejaculation.

Angelica is also used as a smell in aromatherapy to reduce symptoms associated with quitting tobacco (nicotine withdrawal).

Classification

Is a Form of:

Plant

Primary Functions:

Heartburn, intestinal gas, loss of appetite

Also Known As:

American Angelica, Angélica, Angelica acutiloba, Angelica archangelica, Angelica atropurpurea

How Does It Work?

Angelica contains chemicals that might kill cancer cells and fungus, reduce anxiety, and settle the stomach.

Uses

• Indigestion (dyspepsia).A specific combination product containing angelica (Iberogast, Medical Futures, Inc) seems to improve symptoms of upset stomach including acid reflux, stomach pain, cramping, nausea, and vomiting. The combination includes angelica plus peppermint leaf, clown's mustard plant, German chamomile, caraway, licorice, milk thistle, celandine, and lemon balm.

Recommended Dosing

The following doses have been studied in scientific research:

BY MOUTH:

• For indigestion (dyspepsia): A specific combination product containing angelica and several other herbs (Iberogast, Medical Futures, Inc) has been used in a dose of 1 mL three times daily.

Angelica Supplements Frequently Asked Questions

What is Angelica herb good for?

What is Angelica? Angelica is a plant. The root, seed, and fruit are used to make medicine. Angelica is used for heartburn, intestinal gas (flatulence), loss of appetite (anorexia), arthritis, circulation problems, "runny nose" (respiratory catarrh), nervousness, plague, and trouble sleeping (insomnia).

What does Angelica taste like?

Once distilled, angelica has an earthy flavour. It's a little bitter and a little herbal, and is reminiscent of wormwood. The herbal tones carry through to the nose, with a faintly nettle-like smell. The flavour of angelica can sometimes be mistaken for that of juniper berries – though the two are quite separate.

Is Angelica the same as dong quai?

Angelica sinensis, also known as dong quai, is a fragrant plant with a cluster of small white flowers. The flower belongs to the same botanical family as carrots and celery.

What is Angelica powder?

Angelica Root Powder

It is an aromatic plant used in traditional European herbalism for a wide range of wellness support. Our angelica root powder is ground from organic Angelica archangelica roots. ... The plant has an intense yet sweet aroma more like carrots than like dill or fennel.

How do you eat Angelica?

Boil the young leaves and stems to eat as a vegetable or chop the leaves and add to stewed fruit like rhubarb. The sweet-tasting roots are also edible and the aromatic seeds can be used as a culinary spice.

What is Chinese angelica root used for?

Radix Angelica Sinensis, the dried root of Angelica sinensis (Danggui), is a herb used in Chinese medicine to enrich blood, promote blood circulation and modulate the immune system. It is also used to treat chronic constipation of the elderly and debilitated as well as menstrual disorders.

Is Angelica a herb or spice?

Considered a biennial or short-lived perennial, Angelica is a member of the Apiaceae (Umbelliferae or carrot) family which includes anise, celery, cumin, fennel, dill and other plants characterized by feathery leaves, fluted stems and clusters of flowers that emerge from globular umbels.

How do you get angelica seeds?

When they are nearly ripe, fasten a paper bag over the flower head to catch the seeds before they fall to the ground. Use peat or fiber pots so that you won't have to disturb the sensitive roots when you transplant the seedlings into the garden. Press the seeds gently onto the surface of the soil.

What is Angelica made of?

It is known as 'herb of the angels' (hence the name) because it was believed to have medicinal properties. It's a member of the parsley family, a tall plant with a long firm stem and bright green leaves. Candied angelica is made by boiling the stems in sugar syrup.

How tall does Angelica grow?

Characteristics. Angelica species grow to 1–3 m (3 ft 3 in–9 ft 10 in) tall, with large bipinnate leaves and large compound umbels of white or greenish-white flowers.

Can you grow Angelica in pots?

Sow several seeds on the surface of each peat pot. They have a low germination rate and using several seeds in each pot helps insure that seedlings will germinate. After sowing angelica seeds, place the peat pots in a plastic bag and refrigerate them for two to three weeks.

Are Angelica leaves edible?

Boil the young leaves and stems to eat as a vegetable or chop the leaves and add to stewed fruit like rhubarb. The sweet-tasting roots are also edible and the aromatic seeds can be used as a culinary spice.

How do you look after Angelica plants?

Angelica herb is easy to care for as long as it is in well drained soil with proper light exposure. Keep weeds away from the plant and maintain moderately moist soil. Water the plant from the base to prevent fungal diseases. Cut the stalk at the end of the first year to promote flowering in the second.

What is Angelica food?

Angelica. Nutrition. An herb in the parsley family. Pale green, with celerylike stalks and often called wild celery. Angelica is usually candied and used as a decoration on cakes and other desserts;and was the original green candy in fruit cakes.

Does Angelica die after flowering?

Angelica Herb

The umbrella-like flowers are particularly showy but only occur every two years and after bloom the plant often dies. The umbels are white and each spoke of the flower bears a dangling seed after the blooms are spent. ... The root, leaves and seeds are all useful.

Can you eat angelica seeds?

Boil the young leaves and stems to eat as a vegetable or chop the leaves and add to stewed fruit like rhubarb. The sweet-tasting roots are also edible and the aromatic seeds can be used as a culinary spice.

Where is angelica root from?

Angelica is somewhat of a nomadic plant – believed to be a native of Syria, though also grown wild in the Nordics and cultivated in France, Germany, Romania and some East Asian Countries.

When should I plant Angelica?

Planting angelica

Sow seeds in autumn or late spring in modules or directly into the soil. Sow onto the surface of the soil or compost as the seeds need light to germinate. Cut back the stems and dig up the plant in the autumn of its second year, dividing the roots with a sharp knife.

How do you make Angelica tea?

To make angelica tea, add one cup of boiling water to one teaspoon of dried angelica and steep covered for at least 10 minutes. Some alternative practitioners suggest drinking 1/3 cup of angelica tea 30 minutes before each meal.

Clinical Studies

• ^ a b c d Chang A, et al. The effect of herbal extract (EstroG-100) on pre-, peri- and post-menopausal women: a randomized double-blind, placebo-controlled study. Phytother Res. (2012)
• ^ a b c d e f g h i Park SJ, et al. The memory ameliorating effects of INM-176, an ethanolic extract of Angelica gigas, against scopolamine- or Aβ(1-42)-induced cognitive dysfunction in mice. J Ethnopharmacol. (2012)
• ^ Zhang J, et al. Anti-cancer and other bioactivities of Korean Angelica gigas Nakai (AGN) and its major pyranocoumarin compounds. Anticancer Agents Med Chem. (2012)
• ^ a b Joo SS, et al. Anti-allergic effects and mechanisms of action of the ethanolic extract of Angelica gigas in dinitrofluorobenzene-induced inflammation models. Environ Toxicol Pharmacol. (2010)
• ^ a b c d Zhao RJ, et al. The essential oil from Angelica gigas NAKAI suppresses nicotine sensitization. Biol Pharm Bull. (2005)
• ^ a b Konoshima M, Chi HJ, Hata K. Coumarins from the root of Angelica gigas Nakai. Chem Pharm Bull (Tokyo). (1968)
• ^ a b c Lee HJ, et al. In vivo anti-cancer activity of Korean Angelica gigas and its major pyranocoumarin decursin. Am J Chin Med. (2009)
• ^ a b Ahn KS, Sim WS, Kim IH. Decursin: a cytotoxic agent and protein kinase C activator from the root of Angelica gigas. Planta Med. (1996)
• ^ a b c d e Shin S, et al. Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway. J Vet Sci. (2010)
• ^ a b c d Kim EJ, et al. Metabolite profiling of Angelica gigas from different geographical origins using 1H NMR and UPLC-MS analyses. J Agric Food Chem. (2011)
• ^ a b c Decursin and decursinol angelate inhibit VEGF-induced angiogenesis via suppression of the VEGFR-2-signaling pathway.
• ^ a b c d Gigasol and other coumarins from Angelica gigas.
• ^ a b c d e f Kang SY, et al. Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships. J Nat Prod. (2001)
• ^ Choi YE, Ahn H, Ryu JH. Polyacetylenes from angelica gigas and their inhibitory activity on nitric oxide synthesis in activated macrophages. Biol Pharm Bull. (2000)
• ^ Immunostimulating polysaccharide from cell culture of Angelica gigas Nakai.
• ^ a b c d e Kim HM, et al. Antidiabetic activity of angelan isolated from Angelica gigas Nakai. Arch Pharm Res. (2008)
• ^ a b c Immunostimulating components from the root of Angelica gigas Nakai.
• ^ Chung IM, et al. Immunotoxicity activity from various essential oils of Angelica genus from South Korea against Aedes aegypti L. Immunopharmacol Immunotoxicol. (2012)
• ^ HPLC Analysis and Extraction Methods of Decursin and Decursinol Angelate in Angelica gigas Roots.
• ^ a b c d e Jiang C, et al. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res. (2006)
• ^ Jo SK, et al. Antiinflammatory activity of an herbal preparation (HemoHIM) in rats. Phytother Res. (2007)
• ^ a b Kim JJ, et al. Preventative Effect of an Herbal Preparation (HemoHIM) on Development of Airway Inflammation in Mice via Modulation of Th1/2 Cells Differentiation. PLoS One. (2013)
• ^ Kim SH, et al. Protective effect of an herbal preparation (HemoHIM) on radiation-induced intestinal injury in mice. J Med Food. (2009)
• ^ a b c d Song JS, et al. Pharmacokinetic characterization of decursinol derived from Angelica gigas Nakai in rats. Xenobiotica. (2011)
• ^ Kim KM, Kim MJ, Kang JS. Absorption, distribution, metabolism, and excretion of decursin and decursinol angelate from Angelica gigas Nakai. J Microbiol Biotechnol. (2009)
• ^ a b Li L, et al. Single oral dose pharmacokinetics of decursin, decursinol angelate, and decursinol in rats. Planta Med. (2013)
• ^ a b c Li L, et al. Quantitative determination of decursin, decursinol angelate, and decursinol in mouse plasma and tumor tissue using liquid-liquid extraction and HPLC. Planta Med. (2012)
• ^ Park HS, et al. First-pass metabolism of decursin, a bioactive compound of Angelica gigas, in rats. Planta Med. (2012)
• ^ Abd El-Aty AM, et al. In vitro inhibitory potential of decursin and decursinol angelate on the catalytic activity of cytochrome P-450 1A1/2, 2D15, and 3A12 isoforms in canine hepatic microsomes. Arch Pharm Res. (2008)
• ^ Clinical Pharmacokinetics of Theophylline.
• ^ Chae JW, et al. Effect of decursinol angelate on the pharmacokinetics of theophylline and its metabolites in rats. Food Chem Toxicol. (2012)
• ^ a b Park SJ, et al. Neuroprotective effects of INM-176 against lipopolysaccharide-induced neuronal injury. Pharmacol Biochem Behav. (2012)
• ^ a b Li L, et al. Decursin Isolated from Angelica gigas Nakai Rescues PC12 Cells from Amyloid β-Protein-Induced Neurotoxicity through Nrf2-Mediated Upregulation of Heme Oxygenase-1: Potential Roles of MAPK. Evid Based Complement Alternat Med. (2013)
• ^ Li L, et al. Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: the role of Nrf2 and antioxidant enzymes. Biosci Biotechnol Biochem. (2011)
• ^ Choi SS, et al. Antinociceptive mechanisms of orally administered decursinol in the mouse. Life Sci. (2003)
• ^ a b Seo YJ, et al. The analgesic effect of decursinol. Arch Pharm Res. (2009)
• ^ Liu J, Beller D. Aberrant production of IL-12 by macrophages from several autoimmune-prone mouse strains is characterized by intrinsic and unique patterns of NF-kappa B expression and binding to the IL-12 p40 promoter. J Immunol. (2002)
• ^ a b Hwang JT, et al. Decursin, an active compound isolated from Angelica gigas, inhibits fat accumulation, reduces adipocytokine secretion and improves glucose tolerance in mice fed a high-fat diet. Phytother Res. (2012)
• ^ a b c Choi KO, et al. Ultrafine Angelica gigas powder normalizes ovarian hormone levels and has antiosteoporosis properties in ovariectomized rats: particle size effect. J Med Food. (2012)
• ^ a b c d e f g Han SB, et al. Characteristic immunostimulation by angelan isolated from Angelica gigas Nakai. Immunopharmacology. (1998)
• ^ a b c Jeon YJ, et al. Differential activation of murine macrophages by angelan and LPS. Immunopharmacology. (2000)
• ^ Jeon YJ, et al. Activation of NF-kappaB/Rel in angelan-stimulated macrophages. Immunopharmacology. (1999)
• ^ a b c Jeon YJ, Kim HM. Experimental evidences and signal transduction pathways involved in the activation of NF-kappa B/Rel by angelan in murine macrophages. Int Immunopharmacol. (2001)
• ^ Jeon YJ, et al. Activation of mitogen-activated protein kinase pathways by angelan in murine macrophages. Int Immunopharmacol. (2001)
• ^ Hong CH, et al. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol. (2002)
• ^ a b Kim JH, et al. Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages. Mol Pharmacol. (2006)
• ^ Gorbachev AV, Fairchild RL. CD4+ T cells regulate CD8+ T cell-mediated cutaneous immune responses by restricting effector T cell development through a Fas ligand-dependent mechanism. J Immunol. (2004)
• ^ Kitagaki H, et al. Repeated elicitation of contact hypersensitivity induces a shift in cutaneous cytokine milieu from a T helper cell type 1 to a T helper cell type 2 profile. J Immunol. (1997)
• ^ Repeated topical challenge with chemical antigen elicits sustained dermatitis in NC/Nga mice in specific-pathogen-free condition.
• ^ Regulation of macrophage inflammatory protein-2 gene expression in response to 2,4-dinitrofluorobenzene in RAW 264.7 cells.
• ^ Zhang Y, et al. A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo. Invest New Drugs. (2012)
• ^ a b c d e Han SB, et al. Pectic polysaccharide isolated from Angelica gigas Nakai inhibits melanoma cell metastasis and growth by directly preventing cell adhesion and activating host immune functions. Cancer Lett. (2006)
• ^ Jang J, et al. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 and/or mTOR Pathways in Human Multiple Myeloma Cells. Evid Based Complement Alternat Med. (2013)
• ^ Yim D, et al. A novel anticancer agent, decursin, induces G1 arrest and apoptosis in human prostate carcinoma cells. Cancer Res. (2005)
• ^ Ikezoe T, et al. JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA). Br J Cancer. (2004)
• ^ Diacylglycerol (DAG)-lactones, a new class of protein kinase C (PKC) agonists, induce apoptosis in LNCaP prostate cancer cells by selective activation of PKCα.
• ^ a b Woo SM, et al. A New Herbal Formula, KSG-002, Suppresses Breast Cancer Growth and Metastasis by Targeting NF- κ B-Dependent TNF α Production in Macrophages. Evid Based Complement Alternat Med. (2013)
• ^ a b c Kim EY, Rhyu MR. Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigas. J Ethnopharmacol. (2010)
• ^ Kim EY, Rhyu MR. Synergistic vasorelaxant and antihypertensive effects of Ligusticum wallichii and Angelica gigas. J Ethnopharmacol. (2010)
• ^ Mahat B, et al. Physicochemical characterization and toxicity of decursin and their derivatives from Angelica gigas. Biol Pharm Bull. (2012)